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N College of Rheumatology; ANA: antinuclear antibodies; CPK: creatine phosphokinase; dcSSc

N College of Rheumatology; ANA: antinuclear antibodies; CPK: creatine phosphokinase; dcSSc: diffuse PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27906190 cutaneous scleroderma; HRCT: highresolution computed tomography; ILD: interstitial lung illness; IP: immunoprecipitation; IRB: Institutional Review Board; MCTD: mixed connective tissue disease; PM/DM: polymyositis/dermatomyositis; RA: rheumatoid arthritis; RNAP: RNA polymerase; RP: Raynaud's phenomenon; SLE: systemic lupus erythematosus; SS: Sj ren syndrome; SSc: systemic sclerosis: scleroderma; Topo I: topoisomerase I; UCTD: undifferentiated connective tissue disease; UFCAD: 2668-66-8 chemical information University of Florida Center for Autoimmune Diseases. al-Mekaimi A, Malaviya AN, Serebour F, Umamaheswaran I, Kumar R, alSaeid K, Sharma PN: Serological qualities of systemic lupus GSK2879552 erythematosus from a.N College of Rheumatology; ANA: antinuclear antibodies; CPK: creatine phosphokinase; dcSSc: diffuse PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27906190 cutaneous scleroderma; HRCT: highresolution computed tomography; ILD: interstitial lung disease; IP: immunoprecipitation; IRB: Institutional Overview Board; MCTD: mixed connective tissue illness; PM/DM: polymyositis/dermatomyositis; RA: rheumatoid arthritis; RNAP: RNA polymerase; RP: Raynaud's phenomenon; SLE: systemic lupus erythematosus; SS: Sj ren syndrome; SSc: systemic sclerosis: scleroderma; Topo I: topoisomerase I; UCTD: undifferentiated connective tissue illness; UFCAD: University of Florida Center for Autoimmune Illnesses. Acknowledgements We thank Marlene Sarmiento, Annie Chan, plus the UF GCRC staff for assistance with clinical information collection. This study was supported by NIH grant R01-AR40391 and M01R00082 in the U.S. Public Well being Service and by generous gifts from Lupus Hyperlink, Inc. (Daytona Beach, FL) and Mr. Lewis M. Schott towards the University of Florida Center for Autoimmune Disease. Publication of this short article was funded in aspect by the University of Florida Open-Access Publishing Fund. Author specifics 1 Division of Rheumatology and Clinical Immunology, Division of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL, 32610 USA. 2Department PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28154141 of Pathology, Immunology, and Laboratory Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL, 32610 USA. 3 Department of Oral Biology, College of Dentistry, University of Florida, 1395 Center Drive, Gainesville, FL 32610 USA. 4Division of Nephrology, Hypertension, and Renal Transplantation, Division of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL, 32610 USA. Authors' contributions MS, MEK, YL, SJR, and EKLC carried out the immunoassays, and MS designed the study and performed the statistical analysis. MSS, MRB, ESS, and WHR enrolled sufferers for the study and maintained the database. MS, AC, and EKLC drafted the manuscript. All authors read and authorized the final manuscript. Competing interests The authors declare that they have no competing interests.Satoh et al. Arthritis Analysis Therapy 2011, 13:R73 http://arthritis-research.com/content/13/3/RPage six ofReceived: 20 January 2011 Revised: 7 March 2011 Accepted: ten May possibly 2011 Published: 10 May well 2011 References 1. Kuwana M, Kaburaki J, Okano Y, Tojo T, Homma M: Clinical and prognostic associations depending on serum antinuclear antibodies in Japanese patients with systemic sclerosis. Arthritis Rheum 1994, 37:75-83. two. Kuwana M, Kaburaki J, Arnett FC, Howard RF, Medsger TA Jr, Wright TM: Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. Arthritis Rheum 1999, 42:465-474. 3. Steen VD: Autoantibodies in systemic sclerosis. Semin Arthritis Rheum 2005, 35:35-42. 4. Catoggio LJ, Bernstein RM, Black CM, Hughes GR, Maddison PJ: Serological markers in progressive systemic sclerosis: clinical correlations. Ann Rheum Dis 1983, 42:23-27. five. Reveille JD, Solomon DH: Evidence-based suggestions for the use of immunologic tests: anticentromere, Scl-70, and nucleolar antibodies. Arthritis Rheum 2003, 49:399-412. 6. Geisler C, Hoier-Madsen M: An enzyme-linked immunosorbent assay for autoantibodies against the nuclear protein Scl-70.